Piperacillin and Tazobactam for Injection is a combination antibiotic used to treat a variety of bacterial infections. Piperacillin is a penicillin antibiotic that works by killing bacteria, and Tazobactam is a beta-lactamase inhibitor that helps prevent certain bacteria from becoming resistant to the effects of Piperacillin.

Piperacillin and Tazobactam for Injection, provided by Apotex Corporation, is a potent antibacterial treatment designed to combat a wide range of infections. This combination medication is delivered in powder form, contained in 2.25 g vials (10 mL), with each box containing ten vials. The product effectively targets infections caused by susceptible strains of bacteria, offering reliable and comprehensive treatment.

Indications and Usage: This combination is used primarily for the treatment of moderate to severe infections, including:

• Intra-abdominal infections
• Skin and soft tissue infections
• Respiratory tract infections
• Urinary tract infections

Dosage: The typical dosage varies depending on the severity of the infection, patient weight, and renal function. It is administered via intravenous infusion. Healthcare professionals should refer to specific dosing guidelines to ensure safe and effective use.

CDC Guidelines: According to the CDC, antibiotic stewardship is crucial. Prescribing Piperacillin and Tazobactam should be based on susceptibility patterns and clinical judgment. It is essential to reassess the need for continued use as culture results become available.

Details and Features:

• Strength: 2.25 g per vial
• Contents: Each vial contains Piperacillin sodium equivalent to 2 g of Piperacillin and Tazobactam sodium equivalent to 0.25 g of Tazobactam.
• Format: Powder for reconstitution
• Packaging: 10 vials per box

Mechanism of Action: Piperacillin is a broad-spectrum, beta-lactam antibiotic that inhibits bacterial cell wall synthesis. Tazobactam, a beta-lactamase inhibitor, prevents the degradation of Piperacillin by beta-lactamase enzymes, enhancing its effectiveness against resistant bacteria.

Directions:

1. Reconstitute the powder with a compatible diluent as indicated in the prescribing information.
2. Administer intravenously over a period of 30 minutes.
3. Ensure compatibility with other IV medications and solutions.

Warnings:

• Hypersensitivity Reactions: Patients with a history of allergic reactions to penicillins or cephalosporins may be at increased risk.
• Renal Impairment: Dosage adjustments may be necessary.
• Superinfection: Prolonged use may lead to overgrowth of non-susceptible organisms, including fungi.
• Drug Interactions: Monitor for interactions with anticoagulants and other medications metabolized by the liver.

Side Effects:

• Gastrointestinal disturbances (nausea, diarrhea)
• Rash or allergic reactions
• Electrolyte imbalances
• Thrombocytopenia or neutropenia

Consultation with Healthcare Professionals: Always seek the advice of a healthcare provider for diagnosis and treatment options. The details provided herein do not substitute professional medical guidance.