Daptomycin for Injection is an antibiotic used to treat certain bacterial infections. It is particularly effective against Gram-positive bacteria. Daptomycin works by disrupting the bacterial cell membrane, leading to cell death. It is commonly used to treat complicated skin and skin structure infections, bacteremia, and right-sided infective endocarditis caused by susceptible strains of microorganisms. The medication is administered intravenously and is typically reserved for serious infections or when other antibiotics are not suitable. As with any antibiotic, it's important to use it under the guidance of a healthcare professional to ensure its effectiveness and to reduce the risk of resistance.

Daptomycin for Injection by Camber Pharma delivers a potent antibiotic solution designed to treat serious bacterial infections. Each 500 mg vial is tailored for intravenous use, ensuring rapid action against a range of Gram-positive bacteria.

Uses:

Daptomycin is used for:

• Treating complicated skin and skin structure infections (cSSSI)
• Managing Staphylococcus aureus bloodstream infections (bacteremia), including right-sided infective endocarditis

Dosage:

• Specific dosage depends on the type and severity of infection.
• Typical dosing for cSSSI is 4 mg/kg once daily.
• For bacteremia, 6 mg/kg once daily is often recommended.
• Administered via intravenous infusion, usually over 30 minutes.

CDC Guidelines:

The CDC emphasizes the importance of appropriate antibiotic use to prevent resistance. Daptomycin should be used according to susceptibility patterns and in consultation with infectious disease specialists.

Details and Features:

• Concentration: 500 mg per vial
• Formulation: Sterile powder for reconstitution
• Brand: Camber Pharma
• NDC: 31722-0216-01

Mechanism of Action:

Daptomycin disrupts bacterial cell membrane function by binding to it in a calcium-dependent manner, leading to rapid depolarization. This loss of membrane potential inhibits protein, DNA, and RNA synthesis, resulting in bacterial cell death.

Directions:

1. Reconstitute the vial with the recommended diluent.
2. Administer through intravenous infusion under professional supervision.
3. Do not shake vigorously; swirl gently to dissolve.
4. Use immediately after preparation to ensure sterility.

Warnings:

• Monitor for muscle pain or weakness, as Daptomycin can cause myopathy.
• Regularly check creatine phosphokinase (CPK) levels.
• Not recommended for pneumonia treatment.
• Use with caution in patients with renal impairment.

Side Effects:

Possible side effects include:

• Gastrointestinal disturbances (nausea, diarrhea)
• Headache
• Insomnia
• Elevated liver enzymes
• Muscle pain or weakness

Consult Healthcare Provider:

Daptomycin should always be administered under the guidance of a qualified healthcare provider. Report any side effects promptly, especially muscle-related symptoms or signs of allergic reactions, for timely intervention.