Allopurinol Sodium Injection is a medication used to manage and treat high levels of uric acid in the blood, commonly seen in conditions such as cancer therapy-induced tumor lysis syndrome. It works by inhibiting the enzyme xanthine oxidase, which is involved in the production of uric acid. This form is used when oral administration is not feasible, allowing for rapid intervention and management in an acute setting. It’s important to be administered under the guidance of a healthcare professional.

Allopurinol Sodium for Injection by Hikma Injectables is a sterile, high-quality formulation specifically designed for intravenous use. This 500 mg single-use vial is intended for the management of elevated uric acid levels associated with chemotherapy, ensuring rapid and effective control.

Uses:

This injectable form of Allopurinol is used to:

• Prevent acute uric acid nephropathy in patients with leukemia, lymphoma, and solid tumor malignancies undergoing chemotherapy
• Manage elevated uric acid levels in patients unable to take oral medication

Dosage:

Typically, the dosage is determined by the healthcare provider based on the patient’s specific needs and condition. It's crucial to follow the prescribed dosage to avoid complications.

CDC Guidelines:

While the CDC does not provide specific guidelines for Allopurinol, they emphasize the importance of managing uric acid levels to prevent complications in chemotherapy patients.

Details and Features:

• Concentration: 500 mg of Allopurinol Sodium per vial
• Formulation: Sterile, single-use vial for intravenous infusion
• Brand: Hikma Injectables

Mechanism of Action:

Allopurinol acts by inhibiting xanthine oxidase, an enzyme involved in the conversion of hypoxanthine and xanthine to uric acid. This reduces uric acid production, helping prevent kidney damage and other complications associated with high uric acid levels.

Directions:

1. For intravenous infusion only.
2. Reconstitute the vial with appropriate diluent before administration.
3. Administer under the supervision of a healthcare professional.
4. Use immediately after preparation to ensure sterility.

Warnings:

• Hypersensitivity reactions may occur; discontinue if any severe reactions appear.
• For hospital and clinical settings only.
• Not for use in patients who have demonstrated hypersensitivity to Allopurinol.
• Monitor renal function regularly.

Side Effects:

Some potential side effects include:

• Rash or allergic reactions
• Gastrointestinal disturbances (nausea, vomiting)
• Altered liver function tests
• Infusion site reactions

Consult Healthcare Provider:

Always ensure that Allopurinol is administered under the guidance of a qualified healthcare professional. Monitor kidney and liver function regularly to detect any adverse effects promptly. Discontinue use and seek medical attention if serious side effects occur.