Dihydroergotamine Mesylate Nasal Spray is a medication used for the treatment of acute migraine headaches with or without aura. It is especially useful for patients who find oral medications ineffective or unsuitable due to nausea.

Key Details of Dihydroergotamine Mesylate Nasal Spray by Advagen Pharma:

Active Ingredient: Dihydroergotamine Mesylate, a medication belonging to the ergot alkaloid class, which works by constricting blood vessels around the brain and is used to relieve headache.

Strength and Formulation: Each nasal spray delivers 4 mg of dihydroergotamine mesylate per use, allowing for rapid absorption through the nasal mucosa.

Indications:

Acute treatment of migraine headaches with or without aura in adults.
Not intended for prophylactic therapy to prevent migraines.

Dosage and Administration:

• The dose usually involves nasally administering the spray as specified by a healthcare provider, often starting as a single spray.
  
• It's important not to exceed the recommended dosage, which can lead to serious side effects.
  
• Patients should prime the nasal spray before first use following the package instructions.

Contraindications:

• Patients with history of cardiovascular diseases, uncontrolled hypertension, or hypersensitivity to ergotamine compounds.
• Not to be used in combination with potent CYP3A4 inhibitors or within 24 hours of other ergotamine-type medications and triptans.

Precautions:

• Patients should inform their healthcare provider of any existing medical conditions, especially liver or kidney problems.
• Should not be used during pregnancy due to potential adverse effects on the fetus and is advised against during breastfeeding.

Side Effects:

• Possible side effects include nausea, dizziness, fatigue, and, in some cases, more severe vasospasm leading to ischemic complications.
  
• Users should seek immediate medical attention if they experience serious side effects such as chest pain or signs of high blood pressure.

Storage: 

• Store at room temperature away from moisture and heat.
• Keep out of reach of children and dispose of responsibly if expired or no longer needed.

Before using Dihydroergotamine Mesylate Nasal Spray, it is vital for patients to read the medication guide provided and consult with their healthcare provider for personalized medical advice suited to their condition.